几种C_6～C_8重整芳烃脱烯烃技术的工程比选

C6~C8重整芳烃脱烯烃的目的是为了生产合格的苯、甲苯以及二甲苯产品,本文介绍了国内外几种整芳烃脱烯烃的技术的概况,并以某芳烃抽提装置为例,根据不同的脱烯烃技术在流程、催化剂选用上的差异,从主要技术指标和经济指标的角度分析对比,从而选出适合作为特定装置的工程设计方案。     

油气田环境中的器材选用

本文详细的分析了油气田环境中常见的腐蚀类型,包括湿硫化氢腐蚀、氯化物应力腐蚀开裂。并提出不同工况下管道器材的选用、试验方案,安全阀及仪表的选材及选型。     

In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against Atrazine

Widespread use of the chlorotriazine herbicide, atrazine, has led to serious environmental and human health consequences. Current methods of detecting atrazine contamination are neither rapid nor cost-effective. In this work, atrazine-specific single-stranded DNA (ssDNA) molecular recognition elements (MRE) were isolated. We utilized a stringent Systematic Evolution of Ligands by Exponential Enrichment (SELEX) methodology that placed the greatest emphasis on what the MRE should not bind to. After twelve rounds of SELEX, an atrazine-specific MRE with high affinity was obtained. The equilibrium dissociation constant (K_d) of the ssDNA sequence is 0.62 ± 0.21 nM. It also has significant selectivity for atrazine over atrazine metabolites and other pesticides found in environmentally similar locations and concentrations. Furthermore, we have detected environmentally relevant atrazine concentrations in river water using this MRE. The strong affinity and selectivity of the selected atrazine-specific ssDNA validated the stringent SELEX methodology and identified a MRE that will be useful for rapid atrazine detection in environmental samples.     

注塑模具成型部件的失效分析及选材新发展

表面磨损、塑性变形及断裂是注塑模具成型部件在力和热作用下的主要失效形式。作者在对这三种失效分析的基础上,通过目前新研制的注塑模具钢举例的方式,详细叙述了注塑模成型部件材料选择新发展。     

Design of a General‐Purpose European Compound Screening Library for EU‐OPENSCREEN

This work describes a collaborative effort to define and apply a protocol for the rational selection of a general‐purpose screening library, to be used by the screening platforms affiliated with the EU‐OPENSCREEN initiative. It is designed as a standard source of compounds for primary screening against novel biological targets, at the request of research partners. Given the general nature of the potential applications of this compound collection, the focus of the selection strategy lies on ensuring chemical stability, absence of reactive compounds, screening‐compliant physicochemical properties, loose compliance to drug‐likeness criteria (as drug design is a major, but not exclusive application), and maximal diversity/coverage of chemical space, aimed at providing hits for a wide spectrum of drugable targets. Finally, practical availability/cost issues cannot be avoided. The main goal of this publication is to inform potential future users of this library about its conception, sources, and characteristics. The outline of the selection procedure, notably of the filtering rules designed by a large committee of European medicinal chemists and chemoinformaticians, may be of general methodological interest for the screening/medicinal chemistry community. The selection task of 200K molecules out of a pre‐filtered set of 1.4M candidates was shared by five independent European research groups, each picking a subset of 40K compounds according to their own in‐house methodology and expertise. An in‐depth analysis of chemical space coverage of the library serves not only to characterize the collection, but also to compare the various chemoinformatics‐driven selection procedures of maximal diversity sets. Compound selections contributed by various participating groups were mapped onto general‐purpose self‐organizing maps (SOMs) built on the basis of marketed drugs and bioactive reference molecules. In this way, the occupancy of chemical space by the EU‐OPENSCREEN library could be directly compared with distributions of known bioactives of various classes. This mapping highlights the relevance of the selection and shows how the consensus reached by merging the five different 40K selections contributes to achieve this relevance. The approach also allows one to readily identify subsets of target‐ or target‐class‐oriented compounds from the EU‐OPENSCREEN library to suit the needs of the diverse range of potential users. The final EU‐OPENSCREEN library, assembled by merging five independent selections of 40K compounds from various expert groups, represents an excellent example of a Europe‐wide collaborative effort toward the common objective of building best‐in‐class European open screening platforms.     

立交桥桥台桩基托换基坑支护设计与监测

以郑州市中州大道黄河路立交桥匝道F26号桥台桩基托换工程基坑支护为例,提出了一种明挖和暗挖相结合的施工方案,及采用土钉墙喷锚、钻孔灌注桩和内支撑相结合的复合支护结构。采用远程自动化监测和人工监测相结合的数据监测方式,对支护结构进行实时数据监测。支护效果表明:支护结构和施工方案合理,边坡和周边地表变形得到有效控制,包含暗挖通道在内的基坑周边地表最大沉降为12 mm,最大水平位移为13 mm,均小于规范中规定的控制值;在整个施工过程中,基坑周边及上部道路交通未受到较大影响;数据监测系统为安全施工提供了参考,使得整个工程顺利完成。     

基于共享单车大数据的城市型自行车绿道选线规划途径研究

城市型自行车绿道对于鼓励居民慢行出行,缓解城市交通拥堵具有非常重要的价值。从共享单车社会行为大数据和绿地空间利用潜力分析两方面内容入手,构建了一个基于实际使用需求和城区可建设空间的城市型自行车绿道选线规划途径,并以北京海淀区为例开展实证探索。选线规划途径主要包括:利用共享单车起点—终点数据,并运用熵值法建立评价指标体系进行绿地节点利用潜力分析,确定关键连接节点;通过共享单车轨迹数据得到自行车使用的道路热度,提取现状线性绿地廊道,生成自行车绿道连接的土地适宜性成本栅格;利用连接节点和成本栅格计算最低成本路径,划定绿道选线。该选线途径将随着城市大数据的进一步丰富和准确而得到完善,具有很好的未来应用前景。     

少动鞘氨醇单胞菌临床易感因素分析及药物治疗策略

目的:了解医院少动鞘氨醇单胞菌易感因素及耐药特点。方法:回顾性分析7例病原学检查提示少动鞘氨醇单胞菌患者的基础疾病、标本来源、抗菌药物用药史和药物敏感性试验。结果:少动鞘氨醇单胞菌对碳青霉烯类及复方新诺明的敏感性较好,对氨基糖苷类及氟喹诺酮类有一定敏感性,对氨曲南和三代头孢敏感性差。结论:少动鞘氨醇单胞菌宿主易感因素除了以往报道的免疫缺陷、肺部感染、广谱抗生素用药史,还可能存在低蛋白血症及乙型病毒性肝炎病史等因素。治疗用药应避免选择氨曲南及三代头孢。     

基于声信号处理的窨井盖盗毁检测方法

为遏制偷盗和毁坏窨井盖行为,提出一种利用声信号对窨井盖偷盗和毁坏进行检测的方法。因不同声信号的能量基于频率的分布存在差异,将窨井盖产生的振动声信号进行FFT变换,将变换后的频谱转化为能量谱,利用统计方法确定窨井盖振动声信号能量在频率上的特征分布区间和分布阈值,计算其他干扰声信号的20个最大能量点在该特征区间的概率分布数并与阈值对比,判断窨井盖的振动声是否是遭受盗毁时敲击引起的。实验结果显示:窨井盖敲击声的能量分布与其他声信号具有明显不同,其能量分布的特征频率为48～504 Hz,分布阈值为85%。该方法能够有效识别盗毁窨井盖声音,且在一定信噪比环境下具有较强鲁棒性。     

电缆实体火灾模拟实验与电缆的选用

介绍了电缆（支架明敷、支架穿管明敷、防火桥架内敷设、防火桥架内穿管敷设、穿管埋墙暗敷5种电缆敷设方式）实体火灾模拟实验的结果，分析了不同类型的电缆的选用。鉴于矿物绝缘电缆良好的耐火性能。推荐使用。